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Serious lymphocytic leukemia can be a well-outlined lymphoid neoplasm with pretty heterogeneous biological and medical habits. The last ten years has become remarkably fruitful in novel results, elucidating multiple components of the pathogenesis on the condition including mechanisms of genetic susceptibility, insights in the relevance of immunogenetic aspects driving the disease, profiling of genomic alterations, epigenetic subtypes, world epigenomic tumor cell reprogramming, modulation of tumor mobile and microenvironment interactions, and dynamics of clonal evolution from early measures in monoclonal B-mobile lymphocytosis to progression and transformation into diffuse significant B-cell lymphoma.

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